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Article

The Exact Stochastic Process of the Haploid Multi-Allelic Wright-Fisher Mutation Model.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Noland Jonas Kristiansen, Thorvaldsen Steinar

Abstract excerpt

Diffusion models are widely applied in population genetics, but their approximate solutions may not accurately capture the exact stochastic process. Nevertheless, this practice was necessary due to computing limitations, particularly for large populations. In this article, we develop the exact Markov chain algebra (MCA) for a discrete haploid multi-allelic Wright-Fisher model (MA-WFM) with a full mutation matrix...

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Identifiers

PMID: 38010931
DOI: 10.1109/TCBB.2023.3336850

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