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Concordance of Genomic Alterations by Next-Generation Sequencing in Tumor Tissue versus Circulating Tumor DNA in Breast Cancer.

Molecular cancer therapeutics - 1 Jul 2017

Chae Young Kwang, Davis Andrew A, Jain Sarika, Santa-Maria Cesar, Flaum Lisa, Beaubier Nike, Platanias Leonidas C, Gradishar William, Giles Francis J, Cristofanilli Massimo

Abstract excerpt

While identifying genomic alterations in tumor tissue is the current gold-standard technique for molecular profiling, circulating tumor DNA (ctDNA) represents a noninvasive method of assessing genomic alterations using peripheral blood. The concordance of genomic alterations between two commercially available ctDNA and tissue biopsies was compared in 45 patients with breast cancer using paired next-generation...

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Identifiers

PMID: 28446639
DOI: 10.1158/1535-7163.MCT-17-0061

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BRCA1
BRCA2
ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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