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SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging

24 Jun 2014

Abstract excerpt

STUDY QUESTION: Is SIRT1 involved in the oxidative stress (OS) response in mouse oocytes? SUMMARY ANSWER: SIRT1 plays a pivotal role in the adaptive response of mouse germinal vesicle (GV) oocytes to OS and promotes a signalling cascade leading to up-regulation of the MnSod gene. WHAT IS KNOWN ALREADY: OS is known to continuously threaten acquisition and maintenance of oocyte developmental potential during in...

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PMID: 24963165
DOI: 10.1093/humrep/deu160

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