Article
Clinical profile and mutation spectrum of long QT syndrome in Saudi Arabia: The impact of consanguinity.
Heart rhythm - 1 Aug 2017
Al-Hassnan Zuhair N, Al-Fayyadh Majid, Al-Ghamdi Bander, Shafquat Azam, Mallawi Yaseen, Al-Hadeq Faten, Tulbah Sahar, Shinwari Zarghuna M A, Almesned Abdulrahman, Alakhfash Ali, Al Fadly Fadel, Hersi Ahmed S, Alhayani Abdullah, Al-Hashem Amal, Arafah Dia, Dzimiri Nduna, Meyer Brian, Rababh Monther, Al-Manea Waleed
Abstract excerpt
BACKGROUND: Congenital long QT syndrome (LQTS) is an inherited, potentially fatal arrhythmogenic disorder. At least 16 genes have been implicated in LQTS; the yield of genetic analysis of 3 genes (KCNQ1, KCNH2, and SCN5A) is about 70%, with KCNQ1 mutations accounting for ∼50% of positive cases. LQTS is mostly inherited in an autosomal dominant pattern. Systemic analysis of LQTS has not been previously conducted...
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