Article
The Iron Chaperone Protein CyaY from Vibrio cholerae Is a Heme-Binding Protein.
Biochemistry - 9 May 2017
Uchida Takeshi, Kobayashi Noriyuki, Muneta Souichiro, Ishimori Koichiro
Abstract excerpt
CyaY is an iron transport protein for iron-sulfur (Fe-S) cluster biosynthetic systems. It also transports iron to ferrochelatase that catalyzes insertion of Fe2+ into protoporphyrin IX. Here, we find that CyaY has the ability to bind heme as well as iron, exhibiting an apparent dissociation constant for heme of 21 ± 6 nM. Absorption and resonance Raman spectra revealed that both ferric and ferrous forms of heme...
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