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Article

Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.

Archives of oral biology - 1 Aug 2017

Margiotti Katia, Pascolini Giulia, Consoli Federica, Guida Valentina, Di Bonaventura Carlo, Giallonardo Anna Teresa, Pizzuti Antonio, De Luca Alessandro

Abstract excerpt

OBJECTIVE: Gingival overgrowth is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressants, and calcium channel blockers. One of the main drugs associated with gingival overgrowth is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. It has been shown that mutation of human SOS1 gene is responsible for a rare...

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Identifiers

PMID: 28433619
DOI: 10.1016/j.archoralbio.2017.04.002

Genes

SOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.PMID 28433619Read ↗

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