Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Swamikannu Bhuminathan, Kumar Kishore S, Jayesh Raghavendra S, Rajendran Senthilnathan, Muthupalani Rajendran Shanmugam, Ramanathan Arvind

Abstract excerpt

BACKGROUND: Dilantin sodium (phenytoin) is an antiepileptic drug, which is routinely used to control generalized tonic clonic seizure and partial seizure episodes. A few case reports of oral squamous cell carcinomas arising from regions of phenytoin induced gingival overgrowth (GO), and overexpression of mitogenic factors and p53 have presented this condition as a pathology with potential to transform into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Mouth Neoplasms

Share to Phenytoin

Share to Phosphatidylinositol 3-Kinases

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 23803025
DOI: 10.7314/apjcp.2013.14.5.2743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth.PMID 23803025Read ↗

Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature.Semantic proximity Read ↗

Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.Semantic proximity Read ↗

"p53 mutation spectrum and its role in prognosis of oral cancer patients: A study from Gujarat, West India".Semantic proximity Read ↗

The p16INK4alpha/p19ARF gene mutations are infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas.Semantic proximity Read ↗

[Genic alterations in oral and head and neck squamous cell carcinomas: analysis of international literature].Semantic proximity Read ↗

p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation.Semantic proximity Read ↗

Germ Line Gain of Function with SOS1 Mutation in Hereditary Gingival FibromatosisSemantic proximity Read ↗

Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.Semantic proximity Read ↗

Mutations of the cell cycle arrest gene p21WAF1, but not the metastasis-inducing gene S100A4, are frequent in oral squamous cell carcinomas from Sudanese toombak dippers and non-snuff-dippers from the Sudan, Scandinavia, USA and UK.Semantic proximity Read ↗

PTCH-1 and MDM2 expression in ameloblastoma from a West African sub-population: implication for chemotherapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.