Article
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
British journal of cancer - 23 May 2017
Meulendijks Didier, Henricks Linda M, Jacobs Bart A W, Aliev Abidin, Deenen Maarten J, de Vries Niels, Rosing Hilde, van Werkhoven Erik, de Boer Anthonius, Beijnen Jos H, Mandigers Caroline M P W, Soesan Marcel, Cats Annemieke, Schellens Jan H M
Abstract excerpt
BACKGROUND: We investigated the predictive value of dihydropyrimidine dehydrogenase (DPD) phenotype, measured as pretreatment serum uracil and dihydrouracil concentrations, for severe as well as fatal fluoropyrimidine-associated toxicity in 550 patients treated previously with fluoropyrimidines during a prospective multicenter study. METHODS: Pretreatment serum concentrations of uracil and dihydrouracil were...
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