Article
DPYD genotyping and 5-fluoropyrimidine toxicity: An overview of systematic reviews protocol.
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria - 1 Jan 2024
Torres Sara Otero, Pérez Olalla Montero, Mauriz Rosa Rodríguez, Casamartina Eduard Fort, Martínez Sandra Fontanals, Estela Ana Clopés
Abstract excerpt
INTRODUCTION: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase (DPD) deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in DPD deficient patients. The...
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