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Article

Limited impact of intratumour heterogeneity on molecular risk assignment in endometrial cancer.

Oncotarget - 11 Apr 2017

van Esterik Manouk, Van Gool Inge C, de Kroon Cor D, Nout Remi A, Creutzberg Carien L, Smit Vincent T H B M, Bosse Tjalling, Stelloo Ellen

Abstract excerpt

INTRODUCTION: Individual prediction of tumour behaviour based on molecular markers may refine adjuvant treatment strategies in endometrial cancer (EC). As these molecular alterations are determined in a small tumour fraction, high intratumour heterogeneity may interfere with correct risk prediction. This study aimed to investigate to which extent intratumour heterogeneity exists for molecular markers and whether...

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Source

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Identifiers

PMID: 28424422
DOI: 10.18632/oncotarget.16067
PMCID: PMC5421949

Genes

CTNNB1
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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