Article
Hobnail variant of papillary thyroid carcinoma: molecular profiling and comparison to classical papillary thyroid carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma.
Oncotarget - 28 Mar 2017
Teng Lianghong, Deng Wanglong, Lu Junliang, Zhang Jing, Ren Xinyu, Duan Huanli, Chuai Shannon, Duan Feidie, Gao Wei, Lu Tao, Wu Huanwen, Liang Zhiyong
Abstract excerpt
BACKGROUND: As a rare but aggressive papillary thyroid carcinoma (PTC) variant, the genetic changes of hobnail variant of PTC (HVPTC) are still unclear. RESULTS: The prevalence of HVPTC was 1.69% (18/1062) of all PTC diagnosed in our cohort. 73 samples from 55 patients (17 HVPTC, 26 CPTC, 7 PDTC and 5 ATC) were successfully analyzed using targeted NGS with an 18-gene panel. Thirty-seven mutation variant types...
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