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Article

Search for new genetic biomarkers in poorly differentiated and anaplastic thyroid carcinomas using next generation sequencing.

Anticancer research - 1 Apr 2015

Sykorova Vlasta, Dvorakova Sarka, Vcelak Josef, Vaclavikova Eliska, Halkova Tereza, Kodetova Daniela, Lastuvka Petr, Betka Jan, Vlcek Petr, Reboun Martin, Katra Rami, Bendlova Bela

Abstract excerpt

BACKGROUND: Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are very rare tumors with extremely aggressive behavior. Their comprehensive genetic background is still unclear. Some of the main genetic changes of differentiated thyroid carcinomas, such as mutations in BRAF and RAS genes, as well as changes in CTNNB1, PIK3CA, TP53, AXIN1, PTEN or APC genes leading to the...

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Source

Identifiers

PMID: 25862857

Genes

APC
AXIN1
BRAF
CTNNB1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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