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Article

Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.

Oncotarget - 28 Mar 2017

Fleyshman Daria, Prendergast Laura, Safina Alfiya, Paszkiewicz Geraldine, Commane Mairead, Morgan Kelsey, Attwood Kristopher, Gurova Katerina

Abstract excerpt

Although breast cancer (BrCa) may be detected at an early stage, there is a shortage of markers that predict tumor aggressiveness and a lack of targeted therapies. Histone chaperone FACT, expressed in a limited number of normal cells, is overexpressed in different types of cancer, including BrCa. Recently, we found that FACT expression in BrCa correlates with markers of aggressive BrCa, which prompted us to...

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Source

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Identifiers

PMID: 28423528
DOI: 10.18632/oncotarget.15656
PMCID: PMC5400524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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