Article
The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement.
PloS one - 1 Jan 2017
Cavaliere Filomena Monica, Prezzo Alessandro, Bilotta Caterina, Iacobini Metello, Quinti Isabella
Abstract excerpt
The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a normal expression of receptors involved in the activation and cellular responses. We demonstrate that BTK is not...
Topics
- Adult
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- Calcium
- Calcium Chelating Agents
- Case-Control Studies
- Cell Movement
- Drug Administration Schedule
- Gene Expression Regulation
- Genetic Diseases, X-Linked
- Humans
- Immunoglobulins, Intravenous