Article
SAK-HV Decreases the Self-Ubiquitination of MEKK1 to Promote Macrophage Proliferation via MAPK/ERK and JNK Pathways.
International journal of molecular sciences - 19 Apr 2017
Zhang Chao, Chen Yao, Gan Xiangdong, Huang Zhiguang, Zou Minji, Fu Wenliang, Xing Weiwei, Xu Donggang
Abstract excerpt
SAK-HV is an anti-atherosclerosis recombinant fusion protein developed by our lab. Our study determined that SAK-HV promoted macrophage proliferation, of which the mechanism was explored by both RAW264.7 cells and primary macrophages. Mass spectrometric analysis and co-immunoprecipitation were combined to screen the SAK-HV-interacting proteins in RAW264.7 cells. Confocal microscopy was adopted to detect the...
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