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Article

Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML

18 Apr 2017

Abstract excerpt

Abstract Purpose: Cell-to-cell variability in apoptosis signaling contributes to heterogenic responses to cytotoxic stress in clinically heterogeneous neoplasia, such as acute myeloid leukemia (AML). The BCL-2 proteins BAX and BAK can commit mammalian cells to apoptosis and are inhibited by retrotranslocation from the mitochondria into the cytosol. The subcellular localization of BAX and BAK could determine the...

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PMID: 28420723
DOI: 10.1158/1078-0432.ccr-16-1941

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