Article

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia

2020-11-04

Abstract excerpt

Background: Recent randomized trials have demonstrated improvements in overall survival (OS) for the BCL-2 inhibitor venetoclax (VEN) in combination with azacitidine and low dose cytarabine in older unfit patients with AML. Pre-clinical studies identified BAX deficiency as a potential mechanism of VEN resistance in AML, but this has not been observed in patients to date (Chen, Cancer Disc 2019). Methods: Patient s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9301f4eb-5a5e-51b7-a792-b248b319de09
DOI: 10.1182/blood-2020-136872

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid LeukemiaDOI 10.1182/blood-2020-136872Read

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.Semantic proximity Read

Venetoclax Resistance in Acute Myeloid LeukemiaSemantic proximity Read

Venetoclax resistance: mechanistic insights and future strategiesSemantic proximity Read

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugsSemantic proximity Read

Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid LeukemiaSemantic proximity Read

A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid LeukemiaSemantic proximity Read

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AMLSemantic proximity Read

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimeticsSemantic proximity Read

Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AMLSemantic proximity Read

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML CellsSemantic proximity Read

Somatic Missense Mutations at the MCL-1 BH3-Binding Groove Paradoxically Enhance BAK Sequestration: Computational Evidence for Apoptotic ResistanceSemantic proximity Read