Article
Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones.
Oncotarget - 30 May 2017
Carrà Giovanna, Panuzzo Cristina, Torti Davide, Parvis Guido, Crivellaro Sabrina, Familiari Ubaldo, Volante Marco, Morena Deborah, Lingua Marcello Francesco, Brancaccio Mara, Guerrasio Angelo, Pandolfi Pier Paolo, Saglio Giuseppe, Taulli Riccardo, Morotti Alessandro
Abstract excerpt
Chronic Lymphocytic Leukemia (CLL) is a lymphoproliferative disorder with either indolent or aggressive clinical course. Current treatment regiments have significantly improved the overall outcomes even if higher risk subgroups - those harboring TP53 mutations or deletions of the short arm of chromosome 17 (del17p) - remain highly challenging. In the present work, we identified USP7, a known de-ubiquitinase with...
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