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Article

Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR.

Oncotarget - 4 Apr 2017

Della Corte Carminia Maria, Malapelle Umberto, Vigliar Elena, Pepe Francesco, Troncone Giancarlo, Ciaramella Vincenza, Troiani Teresa, Martinelli Erika, Belli Valentina, Ciardiello Fortunato, Morgillo Floriana

Abstract excerpt

PURPOSE: The aim of this work was to investigate the efficacy of sequential treatment with first-, second- and third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and the mechanisms of acquired resistance occurring during the sequential use of these inhibitors. EXPERIMENTAL DESIGN: We developed an in vivo model of acquired resistance to EGFR-inhibitors by treating nude mice...

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Identifiers

PMID: 28416737
DOI: 10.18632/oncotarget.15479
PMCID: PMC5410282

Genes

EGFR
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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