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Article

Data‐driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration

23 Mar 2017

Abstract excerpt

INTRODUCTION: Longitudinal imaging of neurodegenerative disorders is a potentially powerful biomarker for use in clinical trials. In Alzheimer's disease, studies have demonstrated that empirically derived regions of interest (ROIs) can provide more reliable measurement of disease progression compared with anatomically defined ROIs. METHODS: We set out to derive ROIs with optimal effect size for quantifying...

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PMID: 28413716
DOI: 10.1002/brb3.675

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