Article
Socioeconomic Status Interacts with the Genetic Effect of a Chromosome 9p21.3 Common Variant to Influence Coronary Artery Calcification and Incident Coronary Events in the Heinz Nixdorf Recall Study (Risk Factors, Evaluation of Coronary Calcium, and Lifestyle).
Circulation. Cardiovascular genetics - 1 Apr 2017
Schmidt Börge, Frölich Stefanie, Dragano Nico, Frank Mirjam, Eisele Lewin, Pechlivanis Sonali, Forstner Andreas J, Nöthen Markus M, Mahabadi Amir A, Erbel Raimund, Moebus Susanne, Jöckel Karl-Heinz
Abstract excerpt
BACKGROUND: Genetic variants of a locus within the chromosome 9p21.3 region are consistently associated with coronary artery disease and coronary artery calcification (CAC). The aim of this study was to examine whether a 9p21.3 common variant interacts with socioeconomic status (SES) to influence CAC and incident coronary events in a population-based cohort. METHODS AND RESULTS: 9p21.3 single nucleotide...
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