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Exome sequencing identifies genes for socioeconomic status in 350,770 individuals.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jan 2025

Wu Xin-Rui, Yang Liu, Wu Bang-Sheng, Liu Wei-Shi, Deng Yue-Ting, Kang Ju-Jiao, Dong Qiang, Sahakian Barbara J, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai

Abstract excerpt

Socioeconomic status (SES) is a critical factor in determining health outcomes and is influenced by genetic and environmental factors. However, our understanding of the genetic structure of SES remains incomplete. Here, we conducted a large-scale exome study of SES markers (household income, occupational status, educational attainment, and social deprivation) in 350,770 individuals. For rare coding variants, we...

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PMID: 39772748
DOI: 10.1073/pnas.2414018122

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