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Article

Transcriptomic neuron types vary topographically in function and morphology.

Nature - 1 Feb 2025

Shainer Inbal, Kappel Johannes M, Laurell Eva, Donovan Joseph C, Schneider Martin W, Kuehn Enrico, Arnold-Ammer Irene, Stemmer Manuel, Larsch Johannes, Baier Herwig

Abstract excerpt

Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by a specific combination of differentially expressed genes. Clusters of neurons in transcriptomic space correspond to distinct cell types and in some cases-for example, Caenorhabditis elegans neurons1 and retinal ganglion cells2-4-have been shown to share morphology and function. The zebrafish optic tectum...

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PMID: 39939759
DOI: 10.1038/s41586-024-08518-2
PMCID: PMC11864986

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