Mutational analysis employing a phylogenetic mass tree approach in a study of the evolution of the influenza virus.

Abstract excerpt

A mass based approach has been advanced to enable mutations associated with the evolution of proteins to be both charted and interrogated using phylogenetic trees built solely from the masses of peptides generated upon protein proteolysis. The modified MassTree algorithm identifies and displays all such mutations and calculates the frequency of a particular mutation across a tree. Its significance in terms of its...

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