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Article

In Situ Hot-Spot Assembly as a General Strategy for Probing Single Biomolecules.

Analytical chemistry - 2 May 2017

Liu Huiqiao, Li Qiang, Li Mingmin, Ma Sisi, Liu Dingbin

Abstract excerpt

Single-molecule detection using surface-enhanced Raman spectroscopy (SERS) has attracted increasing attention in chemical and biomedical analysis. However, it remains a major challenge to probe single biomolecules by means of SERS hot spots owing to the small volume of hot spots and their random distribution on substrates. We here report an in situ hot-spot assembly method as a general strategy for probing single...

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PMID: 28394117
DOI: 10.1021/acs.analchem.7b00461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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