Article
Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jul 2013
Custódio Gislaine, Parise Guilherme A, Kiesel Filho Nilton, Komechen Heloisa, Sabbaga Cesar C, Rosati Roberto, Grisa Leila, Parise Ivy Z S, Pianovski Mara A D, Fiori Carmem M C M, Ledesma Jorge A, Barbosa José Renato S, Figueiredo Francisco R O, Sade Elis R, Ibañez Humberto, Arram Sohaila B I, Stinghen Sérvio T, Mengarelli Luciano R, Figueiredo Mirna M O, Carvalho Danilo C, Avilla Sylvio G A, Woiski Thiago D, Poncio Lisiane C, Lima Geneci F R, Pontarolo Roberto, Lalli Enzo, Zhou Yinmei, Zambetti Gerard P, Ribeiro Raul C, Figueiredo Bonald C
Abstract excerpt
PURPOSE: The incidence of pediatric adrenocortical tumors (ACTs) is remarkably high in southern Brazil, where more than 90% of patients carry the germline TP53 mutation R337H. We assessed the impact of early detection of this mutation and of surveillance of carriers. PATIENTS AND METHODS: Free ne...
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