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Article

Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defects†.

Biology of reproduction - 26 May 2020

Devlin Darius J, Agrawal Zaneveld Smriti, Nozawa Kaori, Han Xiao, Moye Abigail R, Liang Qingnan, Harnish Jacob Michael, Matzuk Martin M, Chen Rui

Abstract excerpt

Receptor accessory protein 6 (REEP6) is a member of the REEP/Ypt-interacting protein family that we recently identified as essential for normal endoplasmic reticulum homeostasis and protein trafficking in the retina of mice and humans. Interestingly, in addition to the loss of REEP6 in our knockout (KO) mouse model recapitulating the retinal degeneration of humans with REEP6 mutations causing retinitis pigmentosa...

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Identifiers

PMID: 32101290
DOI: 10.1093/biolre/ioaa024
PMCID: PMC7253788

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