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Article

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.

Nature genetics - 1 May 2017

Priam Pierre, Krasteva Veneta, Rousseau Philippe, D'Angelo Giovanni, Gaboury Louis, Sauvageau Guy, Lessard Julie A

Abstract excerpt

Recent studies suggest that individual subunits of chromatin-remodeling complexes produce biologically specific meaning in different cell types through combinatorial assembly. Here we show that granulocyte development requires SMARCD2, a subunit of ATP-dependent SWI/SNF (BAF) chromatin-remodeling complexes. Smarcd2-deficient mice fail to generate functionally mature neutrophils and eosinophils, a phenotype...

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Source

Identifiers

PMID: 28369034
DOI: 10.1038/ng.3812

Genes

SMARCD2
SMARCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.PMID 28369034Read ↗

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