Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2017

Cai Qingqing, Tu Meifeng, Xu-Monette Zijun Y, Sun Ruifang, Manyam Ganiraju C, Xu Xiaolu, Tzankov Alexander, Hsi Eric D, Møller Michael B, Medeiros L Jeffrey, Ok Chi Young, Young Ken H

Abstract excerpt

Dysregulated NF-κB signaling is critical for lymphomagenesis, however, the expression and clinical relevance of NF-κB subunit p50 in diffuse large B-cell lymphoma have not been evaluated. In this study, we analyzed the prognostic significance and gene expression signatures of p50 nuclear expression as a surrogate for p50 activation in 465 patients with de novo diffuse large B-cell lymphoma. We found that p50+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Murine-Derived
Share to Cyclophosphamide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxorubicin

Share to Lymphoma, Large B-Cell, Diffuse

Share to NF-kappa B p50 Subunit

Share to Prednisone

Share to Rituximab

Share to Vincristine

Source

Identifiers

PMID: 28281555
DOI: 10.1038/modpathol.2017.5

Genes

BCL2
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53.PMID 28281555Read ↗

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.Semantic proximity Read ↗

The molecular pathogenesis of primary mediastinal large B-cell lymphomaSemantic proximity Read ↗

Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic ImplicationsSemantic proximity Read ↗

NF B activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypesSemantic proximity Read ↗

TIRAP p.R81C is a novel lymphoma risk variant which enhances cell proliferation via NF-κB mediated signaling in B-cellsSemantic proximity Read ↗

Genetic drivers of NF-κB deregulation in diffuse large B-cell lymphomaSemantic proximity Read ↗

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomasSemantic proximity Read ↗

Isoform-Specific Functions of p73 Drive Survival and Chemoresistance in Diffuse Large B-Cell LymphomaSemantic proximity Read ↗

Progress in deciphering the role of p53 in diffuse large B-cell lymphoma: mechanisms and therapeutic targetsSemantic proximity Read ↗

Mechanisms of NF-κB deregulation in lymphoid malignancies.Semantic proximity Read ↗

Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell LymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.