Article
Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies.
Heart rhythm - 1 Jul 2017
Sepehrkhouy Shahrzad, Gho Johannes M I H, van Es René, Harakalova Magdalena, de Jonge Nicolaas, Dooijes Dennis, van der Smagt Jasper J, Buijsrogge Marc P, Hauer Richard N W, Goldschmeding Roel, de Weger Roel A, Asselbergs Folkert W, Vink Aryan
Abstract excerpt
BACKGROUND: Desmosomal and phospholamban (PLN) mutations are associated with arrhythmogenic cardiomyopathy. Ultimately, most cardiomyopathic hearts develop significant cardiac fibrosis. OBJECTIVE: To compare the fibrosis patterns of desmosomal and p. Arg14del PLN-associated cardiomyopathies with the pattern in hearts with other hereditary cardiomyopathies. METHODS: A midventricular transversal slice was obtained...
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