Article
Myocardial fibrosis as an early feature in phospholamban p.Arg14del mutation carriers: phenotypic insights from cardiovascular magnetic resonance imaging.
European heart journal. Cardiovascular Imaging - 1 Jan 2019
Te Rijdt Wouter P, Ten Sande Judith N, Gorter Thomas M, van der Zwaag Paul A, van Rijsingen Ingrid A, Boekholdt S Matthijs, van Tintelen J Peter, van Haelst Paul L, Planken R Nils, de Boer Rudolf A, Suurmeijer Albert J H, van Veldhuisen Dirk J, Wilde Arthur A M, Willems Tineke P, van Dessel Pascal F H M, van den Berg Maarten P
Abstract excerpt
Aims: The p.Arg14del founder mutation in the gene encoding phospholamban (PLN) is associated with an increased risk of malignant ventricular arrhythmia (VA) and heart failure. It has been shown to lead to calcium overload, cardiomyocyte damage, and eventually to myocardial fibrosis. This study sought to investigate ventricular function, the extent and localization of myocardial fibrosis and the associations with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.