Article
TGFß3 / SfaN1 gene variant and the risk factor of nonsyndromic cleft palate only among Indonesian patients.
Cellular and molecular biology (Noisy-le-Grand, France) - 28 Feb 2017
Nasroen S L, Tajrin A, Fauziah P N, Maskoen A M, Soemantri E S S, Soedjana H, Hilmanto D
Abstract excerpt
Non-syndromic cleft palate only (NS CPO) is one of the most common congenital malformations that affect between 1 in 1000 - 2500 live births worldwide. The etiopathogenesis of clefts including NS CPO has been widely studied but is still poorly understood. NS CPO is considered to be a genetically complex, multifactorial disease. Based on several studies, mutations of TGFβ3 gene emerged as the strong candidate gene...
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