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Article

Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer.

Molecular medicine reports - 1 May 2017

Bredemeier Maren, Kasimir-Bauer Sabine, Kolberg Hans-Christian, Herold Thomas, Synoracki Sarah, Hauch Siegfried, Edimiris Philippos, Bankfalvi Agnes, Tewes Mitra, Kimmig Rainer, Aktas Bahriye

Abstract excerpt

The aim of the present study was to compare the phosphatidylinositol 3-kinase (PI3KCA)-AKT serine/threonine kinase (AKT) pathway in circulating tumor cells (CTCs) and corresponding cancerous tissues. Stemness‑like circulating tumor cells (slCTCs) and CTCs in epithelial-mesenchymal transition (EMT) have been implicated as the active source of metastatic spread in breast cancer (BC). In this regard, the PI3KCA‑AKT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28358430
DOI: 10.3892/mmr.2017.6415
PMCID: PMC5428904

Genes

AKT2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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