Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis.

Mediators of inflammation - 1 Jan 2017

Crooks James, Gargaro Marco, Vacca Carmine, Volpi Claudia, Pirro Matteo, Scalisi Giulia, Turco Antonella, Romani Rita, Matino Davide, Rostami Abdolmohamad, Puccetti Paolo, Gran Bruno, Fallarino Francesca

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory, demyelinating disease of the CNS that mimics human multiple sclerosis (MS), and it is thought to be driven by Th1 and Th17 myelin-reactive cells. Although adaptive immunity is clearly pivotal in the pathogenesis of EAE, with an essential role of CD4+ T cells, little is known of early, innate responses in this experimental setting. CpG-rich...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endotoxins

Share to Immunity, Innate

Share to Multiple Sclerosis

Share to Oligodeoxyribonucleotides

Share to Spleen

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 28356656
DOI: 10.1155/2017/1380615
PMCID: PMC5357541

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis.PMID 28356656Read ↗

Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitisSemantic proximity Read ↗

Antiinfective Applications of Toll-like Receptor 9 AgonistsSemantic proximity Read ↗

IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig production.Semantic proximity Read ↗

Regulatory T-cells in multiple sclerosis produce IL-10 in the central 1 nervous system but are activated by Epstein-Barr VirusSemantic proximity Read ↗

A Review of the Role of CpG Oligodeoxynucleotides as Toll-Like Receptor 9 Agonists in Prophylactic and Therapeutic Vaccine Development in Infectious DiseasesSemantic proximity Read ↗

Experimental Autoimmune Encephalomyelitis Mediated by CD8<sup>+</sup> T CellsSemantic proximity Read ↗

Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes.Semantic proximity Read ↗

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis.Semantic proximity Read ↗

Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation.Semantic proximity Read ↗

Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal ModelsSemantic proximity Read ↗

Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17‐mediated autoimmunity in the CNSSemantic proximity Read ↗

Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.