Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum

Abstract excerpt

Chloroquine, long the default first-line treatment against malaria, is now abandoned in large parts of the world because of widespread drug-resistance in Plasmodium falciparum. In spite of its importance as a cost-effective and efficient drug, a coherent understanding of the cellular mechanisms affected by chloroquine and how they influence the fitness and survival of the parasite remains elusive. Here, we used a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Malaria Research and Control
• Share to Metabolomics and Mass Spectrometry Studies
• Share to Mosquito-borne diseases and control