Article
Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: Dose-dependent association of plasma cotinine with infant birth size among Japanese women-The Hokkaido Study.
Reproductive toxicology (Elmsford, N.Y.) - 1 Dec 2017
Kobayashi Sumitaka, Sata Fumihiro, Sasaki Seiko, Braimoh Titilola Serifat, Araki Atsuko, Miyashita Chihiro, Goudarzi Houman, Kobayashi Sachiko, Kishi Reiko
Abstract excerpt
OBJECTIVES: We aimed to assess the individual dose-response effects of eight maternal polymorphisms encoding polycyclic aromatic hydrocarbon-metabolizing and DNA-repair genes on prenatal cotinine levels according to infant birth size. METHODS: In total, 3263 Japanese pregnant women were assigned to five groups based on plasma cotinine levels during the 8th month of pregnancy, as measured using ELISA (cut-offs:...
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