Article
Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-Affinity Binding to G-Actin.
Biochemistry - 11 Apr 2017
Watts Norman R, Zhuang Xiaolei, Kaufman Joshua D, Palmer Ira W, Dearborn Altaira D, Coscia Stephen, Blech-Hermoni Yotam, Alfano Caterina, Pastore Annalisa, Mankodi Ami, Wingfield Paul T
Abstract excerpt
Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) is a principal component of the sarcomere. The three prevalent isoforms of ZASP in skeletal muscle are generated by alternative splicing of exons 9 and 10. The long isoforms, either having (ZASP-L) or lacking exon 10 (ZASP-LΔex10), include an N-terminal PDZ domain, an actin-binding region (ABR) with a conserved motif (ZM), and three...
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