Article
Group A Streptococcus strains causing meningitis without distinct invasive phenotype.
MicrobiologyOpen - 1 Feb 2024
Marquardt Laura, Andreoni Federica, Boumasmoud Mathilde, Schweizer Tiziano A, Heuberger Dorothea M, Parietti Elena, Hertegonne Sanne, Epprecht Jana, Mattle Dario, Raez Anna K, Marques-Maggio Ewerton, Schuepbach Reto A, Hasse Barbara, Mairpady-Shambat Srikanth, Brugger Silvio D, Zinkernagel Annelies S
Abstract excerpt
Group A streptococcal (GAS; aka Streptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates derived from five cases of meningitis to otitis and colonizing isolates. We did not observe differences in adherence to and invasion of human brain microvascular endothelial...
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