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Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

7 Feb 2007

Abstract excerpt

Viruses of the family Flaviviridae are important human and animal pathogens. Among them, the Flaviviruses dengue (DENV) and West Nile (WNV) cause regular outbreaks with fatal outcomes. The RNA-dependent RNA polymerase (RdRp) activity of the non-structural protein 5 (NS5) is a key activity for viral RNA replication. In this study, crystal structures of enzymatically active and inactive WNV RdRp domains were...

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Identifiers

PMID: 17287213
DOI: 10.1074/jbc.m607273200

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