Article
Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.
Behavior genetics - 1 Jul 2017
Cho Seung Bin, Aliev Fazil, Clark Shaunna L, Adkins Amy E, Edenberg Howard J, Bucholz Kathleen K, Porjesz Bernice, Dick Danielle M
Abstract excerpt
Twin studies indicate that latent genetic factors overlap across comorbid psychiatric disorders. In this study, we used a novel approach to elucidate shared genetic factors across psychiatric outcomes by clustering single nucleotide polymorphisms based on their genome-wide association patterns. We applied latent profile analysis (LPA) to p-values resulting from genome-wide association studies across three...
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