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A Nonsynonymous SNP Catalog of Mycobacterium tuberculosis Virulence Genes and Its Use for Detecting New Potentially Virulent Sublineages.

Genome biology and evolution - 1 Apr 2017

Mikheecheva Natalya E, Zaychikova Marina V, Melerzanov Alexander V, Danilenko Valery N

Abstract excerpt

Mycobacterium tuberculosis is divided into several distinct lineages, and various genetic markers such as IS-elements, VNTR, and SNPs are used for lineage identification. We propose an M. tuberculosis classification approach based on functional polymorphisms in virulence genes. An M. tuberculosis virulence genes catalog has been established, including 319 genes from various protein groups, such as proteases, cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28338924
DOI: 10.1093/gbe/evx053
PMCID: PMC5381574

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