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Article

TFEB-VEGFA (6p21.1) co-amplified renal cell carcinoma: a distinct entity with potential implications for clinical management.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2017

Gupta Sounak, Johnson Sarah H, Vasmatzis George, Porath Binu, Rustin Jeannette G, Rao Priya, Costello Brian A, Leibovich Bradley C, Thompson R Houston, Cheville John C, Sukov William R

Abstract excerpt

A subset of renal cell carcinomas shows TFEB overexpression secondary to MALAT1-TFEB gene fusion. As alternate mechanisms of TFEB overexpression are likely to have the same effect, we sought to determine the frequency of amplification of TFEB and the adjacent VEGFA gene at 6p21.1. As patients with metastatic renal cell carcinomas are managed with anti-VEGF therapies, we retrospectively assessed therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28338654
DOI: 10.1038/modpathol.2017.24

Genes

TFEB
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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