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Article

TFEB-amplified Renal Cell Carcinomas

26 Aug 2016

Abstract excerpt

Renal cell carcinomas (RCCs) with the t(6;11)(p21;q12) chromosome translocation are low-grade RCC which often occur in young patients. They typically feature an unusual biphasic morphology characterized by nests of larger epithelioid cells surrounding intraluminal collections of smaller cells clustered around basement membrane material. The t(6;11)(p21;q12) translocation fuses the Alpha (MALAT1) gene with the...

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PMID: 27565001
DOI: 10.1097/pas.0000000000000720

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