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Article

PNPLA3 and RNF7 Gene Variants are Associated with the Risk of Developing Liver Fibrosis and Cirrhosis in an Eastern European Population.

Journal of gastrointestinal and liver diseases : JGLD - 1 Mar 2017

Kupcinskas Juozas, Valantiene Irena, Varkalaitė Greta, Steponaitiene Ruta, Skieceviciene Jurgita, Sumskiene Jolanta, Petrenkiene Vitalija, Kondrackiene Jurate, Kiudelis Gediminas, Lammert Frank, Kupcinskas Limas

Abstract excerpt

BACKGROUND AND AIMS: Genome-wide association studies have revealed an association between the risk of developing liver fibrosis or cirrhosis and the single nucleotide polymorphisms (SNPs) of the PNPLA3, RNF7, MERTK and PCSK7 genes. We aimed to validate these results in an Eastern European population. METHODS: We evaluated the associations between the PNPLA3 (rs738409), RNF7 (rs16851720), MERTK (rs4374383) and...

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Source

Identifiers

PMID: 28338112
DOI: 10.15403/jgld.2014.1121.261.pnp

Genes

PNPLA3
RNF7
MERTK
PCSK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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