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Article

Pathogenesis of meningococcal purpura fulminans.

Pathogens and disease - 1 Apr 2017

Lécuyer Hervé, Borgel Delphine, Nassif Xavier, Coureuil Mathieu

Abstract excerpt

Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis. In this review, we discuss the prothrombotic events occurring during meningococcal infection. Moreover, recent data from an experimental mouse model have...

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PMID: 28334263
DOI: 10.1093/femspd/ftx027

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