Article
Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2017
Singh Jatinder, Minster Ryan L, Schupf Nicole, Kraja Aldi, Liu YongMei, Christensen Kaare, Newman Anne B, Kammerer Candace M
Abstract excerpt
BACKGROUND: Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity. METHODS: Using data from the Long Life Family Study, we performed genomewide association analyses on an endophenotype construct, LF1, comprising a linear combination of traits across health domains. LF1 primarily reflected traits...
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