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Article

FLT-1 gene polymorphisms and protein expression profile in rheumatoid arthritis.

PloS one - 1 Jan 2017

Paradowska-Gorycka Agnieszka, Sowinska Anna, Pawlik Andrzej, Malinowski Damian, Stypinska Barbara, Haladyj Ewa, Romanowska-Prochnicka Katarzyna, Olesinska Marzena

Abstract excerpt

OBJECTIVES: Inflammation and angiogenesis are a significant element of pathogenesis in rheumatoid arthritis (RA). The FLT-1- triggering factor for production of proinflammatory cytokines-might contributes to inflammation in patients with RA. Association of the FLT-1 polymorphisms with different "angiogenic diseases" suggests that it may be a novel genetic risk factor also for RA. The aim of the study was to...

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Identifiers

PMID: 28323906
DOI: 10.1371/journal.pone.0172018
PMCID: PMC5360214

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