Article
Neuroanatomic, epigenetic and genetic differences in monozygotic twins discordant for attention deficit hyperactivity disorder.
Molecular psychiatry - 1 Mar 2018
Chen Y-C, Sudre G, Sharp W, Donovan F, Chandrasekharappa S C, Hansen N, Elnitski L, Shaw P
Abstract excerpt
The study of monozygotic twins discordant for attention deficit hyperactivity disorder can elucidate mechanisms that contribute to the disorder, which affects ~7% of children. First, using in vivo neuroanatomic imaging on 14 pairs of monozygotic twins (mean age 9.7, s.d. 1.9 years), we found that discordance for the disorder is mirrored by differing dimensions of deep brain structures (the striatum and...
Topics
- Attention Deficit Disorder with Hyperactivity
- Brain
- Cerebellum
- Child
- Corpus Striatum
- DNA Methylation
- Diseases in Twins
- Epigenesis, Genetic
- Epigenomics
- Female
- Genotype