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Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG

14 Jun 2007

Abstract excerpt

The ends of human chromosomes are protected from the degradation associated with cell division by 15-20 kb long segments of hexameric repeats of 5'-TTAGGG-3' termed telomeres. In normal cells telomeres lose up to 300 bp of DNA per cell division that ultimately leads to senescence; however, most cancer cells bypass this lifespan restriction through the expression of telomerase. hTERT, the catalytic subunit...

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PMID: 17570133
DOI: 10.1002/jcb.21417

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