Article
A Novel Biocontainment Strategy Makes Bacterial Growth and Survival Dependent on Phosphite.
Scientific reports - 20 Mar 2017
Hirota Ryuichi, Abe Kenji, Katsuura Zen-Ichiro, Noguchi Reiji, Moribe Shigeaki, Motomura Kei, Ishida Takenori, Alexandrov Maxym, Funabashi Hisakage, Ikeda Takeshi, Kuroda Akio
Abstract excerpt
There is a growing demand to develop biocontainment strategies that prevent unintended proliferation of genetically modified organisms in the open environment. We found that the hypophosphite (H3PO2, HPt) transporter HtxBCDE from Pseudomonas stutzeri WM88 was also capable of transporting phosphite (H3PO3, Pt) but not phosphate (H3PO4, Pi), suggesting the potential for engineering a Pt/HPt-dependent bacterial...
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